New publication on circRNA and NAFLD

"Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications"

Yepmo M, Potier JB, Pinget M, Grabarz A, Bouzakri K, Dumond Bourie A.



Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that affects 25% of the world's population. Characterized by an accumulation of fat in the liver, the onset of NAFLD is often linked to other metabolic pathologies such as diabetes or obesity. As the disease progresses, it can worsen into a more severe form, non-alcoholic steatohepatitis, or NASH. For some patients, the disease may progress to cirrhosis which could lead to liver transplantation, as no pharmacological treatment exists to date.

In recent years, advances in genomic research have identified a new and unique type of RNA, circular RNAs. The properties of these RNAs in many physiological and pathological contexts have been recently described and they possess pleiotropic properties due to their ability to regulate the expression of many genes and proteins throughout the organism. Through this review, our teams have synthesized the state of the art of the existing literature in order to highlight the impact of certain circular RNAs on the evolution of NAFLD. Thus, we brought a better understanding of the role, beneficial or deleterious, of these new RNAs on the various physiopathological aspects of NAFLD and NASH.

Link to the paper: https://pubmed.ncbi.nlm.nih.gov/36407314/