New publication on NADPH oxidases in healthy white adipose tissue and in obesity

"NADPH oxidases in healthy white adipose tissue and in obesity: function, regulation, and clinical implications"

Jornayvaz FR, Gariani K, Somm E, Jaquet V, Bouzakri K, Szanto I.

NADPH oxidase (NOX)- and dual oxidase (DUOX)-enzymes produce oxidant entities and were recently recognized as novel regulators of white adipose tissue physiological functions and their adaptation in obesity. Our review provides and up-to-date summary of the physiological roles of NOX/DUOX enzymes in healthy metabolism and the pathological alterations associated with their dysfunctions, particularly the onset of Type 2 diabetes.

Our review draws attention to a novel component of Type 2 diabetes development that should be further investigated to provide more precision targeting in the treatment of diabetes and obesity.

Link to the paper and abstract: NADPH oxidases in healthy white adipose tissue and in obesity: function, regulation, and clinical implications - PubMed (nih.gov)